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Title
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Effect of Hibiscus sabdariffa extract on the body weight, complete blood count, liver function, and lipid profile in rabbits
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Abstract
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The objective of the study conducted here was to investigate effect of Hibiscus
sabdariffa extract on the body weight, complete blood count (CBC), liver function, and lipid
profile in rabbits. A total of 20 local male rabbits were randomly divided into four
experimental groups, including five rabbits in each group: (i) control; (ii) starvation; (iii) H.
sabdariffa extract; and (iv) H. sabdariffa extract and starvation. Blood samples were
collected directly from the heart at the end of the experiment (day 28) and used for
complete blood count and estimation of cholesterol, triglycerides, ALT, and AST. Aorta and
liver sections were histopathologically examined. Results indicated that the Body weight at
the end of the study was significantly decreased in starvation, extract, and starvation and
extract groups, compared to the beginning of the study for each group. There was no
difference in the body weight between groups at the end of the study. Rabbits in the extract
group showed significant increase in lymphocytes, RBC, hemoglobin, and platelets,
compared to those in control and in starvation groups. ALT activity significantly increased in
starvation, extract, and starvation and extract groups, compared to those in control group.
AST activity significantly increased in both extract and starvation and extract group,
compared to those in control and starvation groups. Cholesterol and triglycerides decreased
in starvation, extract, and starvation and extract groups, compared to those in control
group. Histopathological sections indicated simple changes in aorta layers in starvation
group rabbits including few number foam cells in tunica media. Liver sections from
starvation group rabbits showed coagulative necrosis of hepatocytes, hyperplasia of bile
duct endothelia, dilation and congestion of central veins. In extract group there was dilation
of central veins, vacuolar degeneration of the hepatocytes, infiltration of inflammatory cells
and hepatic artery congestion. Similar changes were revealed in liver sections from
starvation and extract group. In conclusion, aqueous H. sabdariffa can decrease the body
weight as alternative to the starvation, decrease blood cholesterol and triglycerides, and
increase the immunity; however, daily consumption can have impact on the liver.
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Scientific Type
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تطبيقي
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Journal volume
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vol.7,No.2
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Collaboration type
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منفرد
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Publish Date
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February 1, 2020
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Scopus status
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Not in Scopus
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Clarivate status
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Not In Clarivate
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Pub. Med. status
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Not In PubMed
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ISSN
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1006-7930
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Country (Publication)
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china
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Country type
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عالمية
Alnoor University
College of Health and Medical Technologies
Academic Paper 