EFFECT OF SODIUM FLUORIDE ON SOME PHYSIOLOGICAL PARAMETERS AND HISTOPATHOLOGY IN ADRENAL AND THYROID GLANDS IN ADULT MALE RATS
- Title
- EFFECT OF SODIUM FLUORIDE ON SOME PHYSIOLOGICAL PARAMETERS AND HISTOPATHOLOGY IN ADRENAL AND THYROID GLANDS IN ADULT MALE RATS
- Abstract
-
This study was carried out to investigate the harmful effect of water fluoridation on both
(thyroid and adrenal gland) in adult male rats its weight about (400-300gm) exposed to sodium
fluoride(NaF) in the drinking water. We are used in this study (٣٠) adult male rats (albino) were
distributed randomly and divided into two equal groups (15 animals per group) . The first group
was given normal water and considered as a control group (control group), while the second group
were given drinking water with 100 ppm of sodium fluoride(NaF) (treated group). this study carried
out in the animal house in the college of Vet. Med.\ Tikrit University. blood was drawn through the
eye pupil for periods (0,30,60 days) in order to measure the following parameters: Measurement of
Glutathione(GSH) concentration, total cholesterol and blood glucose concentration . In addition
taking tissue sections of the thyroid and adrenal glands.The results of this study showed that
exposure of animals to sodium fluoride at a concentration of 100 ppm in drinking water for (60)
days cause adrenal and thyroid gland dysfunction, represented by a significant decrease in the level
of glutathione in blood serum on days 30 and 60 of the experiment and a significant increase in total
cholesterol and blood glucose concentrations.The results of the histological examination of the
thyroid gland of the treated group showed hyperplasia of the epithelial cell layer lining the acini
vesicles, and severe lipid changes were seen in the function of Reticularis in the histological
sections of the thyroids gland of the same group animals. The results of this study confirmed the
harmful effect of sodium fluoride(NaF) on thyroid and adrenal functions in addition to its effect on
some biochemical parameters that are indicative of the occurrence of harmful effects of some
chemical compounds - Scientific Type
- اكاديمي
- Journal volume
- vol.19,No.3
- Collaboration type
- مشترك
- Publish Date
- November 1, 2020
- Scopus status
- Not in Scopus
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
انعام عناد جبوري مصطفى
- Journal (Publication)
- Basrah Journal of Veterinary Research
- Publisher (Publication)
- Basrah: University of Basrah
- ISSN
- 2410-8456
- Country (Publication)
-
Iraq
- Country type
- داخل العراق
- College (Publication)
-
College of Health and Medical Technologies
- Departement (Publication)
-
Department of Medical laboratories techniques
- Media
-
Academic Paper
