A novel approach for spectrophotometric determination of naproxen
- Title
- A novel approach for spectrophotometric determination of naproxen
- Abstract
- In the present pandemic , Naproxen is one of the important drugs in which it blocks the binding groove of RNA nucleoprotein of influenza virus, in this paper (S)-2-(6-methooxynaphthalen-2-yl)-(+) propionic acid (Naproxen) has been refluxed with hydrobromic acid and acetic acid to form (S)-2-(6-hydroxynaphthalen-2-yl)-(+) propoinic acid (the hydroxyl analog of Naproxen , HAN). HAN has been oxidized with iron (III) ion followed by complex-formation reaction with 2,2-bipyridyl at 35°C in acidic medium to form an orange-red, complex that is soluble in water with good stability and exhibits maximum absorption at 523 nm. Concentration linearity range was from 0.25 to10 µg/ml of HAN. The calculated molar absorptivity is 6.0×104 l/mol.cm, Sandell’s index for sensitivity is 0.0260 µg/cm2, relative error % is from -0.1 to 0.15,and the rang of relative standard deviation % is from ± 0.10 to ± 0.35 % depending on the concentration level. 0.0132µg/ml is the limit of detection (LOD) and 0.0442 µg/ml is the limit of quantitation (LOQ). Nap has been determined in pure form. The application to the Naproxen Tablets requires an extraction by ethyl acetate in acidic medium.
- Scientific Type
- اكاديمي
- Journal volume
- vol.12,No.2
- Collaboration type
- مشترك
- Publish Date
- December 1, 2020
- Scopus status
- In Scopus
- Scopus index year
- 2 020
- Scopus quarter
- 5
- Scopus citation score
- 0.800000012
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
- ذرى زياد فتح الله حسن
- Journal (Publication)
- INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH
- Publisher (Publication)
- Advanced Scientific Research
- ISSN
- 0975-2366
- Country (Publication)
-
India
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic Paper
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