Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial · Alnoor Digital Repository

Title: Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial
Abstract: Helicobacter pylori infection is a predisposing factor for gastric cancer. This prospective, randomized clinical trial aimed to compare H. pylori eradication rates associated with a clarithromycin-based regimen and levofloxacin-based regimen. H. pylori infection was confirmed by a rapid urease test during endoscopy and its eradication by a urea breath test. In this study, 192 patients were recruited; 93 patients received a clarithromycin- based regimen and 99 a levofloxacin- based regimen. Sixty-four patients completed the clarithromycinbased regimen and 60 the levofloxacinbased regimen. The eradication success rate of the clarithromycin-based regimen was 52/64 (81.25%), while that of the levofloxacin- based regimen was 49/60 (81.6%) (P=0.9524; odds ratio [OR]=1.0280; confidence interval [CI]=0.4153-2.5447). Investigation of the risk factors associated with treatment failure showed that the overall efficacy of the regimens was influenced by body mass index (BMI), with a high failure rate observed in patients with a high BMI (P=0.0174; OR=1.1116; CI=1.0187- 1.2129). Age, sex, endoscopic diagnosis and smoking did not influence treatment outcomes. Further studies are needed to monitor H. pylori antibiotic resistance rates.
Scientific Type: تطبيقي
Link: https://www2.mdpi.com/2036-7422/10/1/8256
Journal volume: vol.10,No.1
Collaboration type: مشترك
Publish Date: September 17, 2019
Participated Universities (Publication): Alnoor University; Duhok University; Zakho University; Azadi Teaching Hospital,Duhok,Iraq
Scopus status: In Scopus
Scopus index year: 2 019
Scopus quarter: 3
Scopus citation score: 0.100000001
Clarivate status: In Clarivate
Clarivate index year: 2 019
Clarivate impafact: 0.125
Pub. Med. status: Not In PubMed
Author (Publication): عمر قتيبة بدر الدين محمود
Journal (Publication): Gastroenterology Insights
Publisher (Publication): Multidisciplinary Digital Publishing Institute (MDPI)
ISSN: 2036-7422
Country (Publication): Switzerland
Country type: عالمية
College (Publication): College of Pharmacy
Departement (Publication): Department of Pharmacy

Media: Academic Paper