Hepatic injury in COVID-19 Patients

Title

Hepatic injury in COVID-19 Patients

Abstract

The practical studies have already proved that the laboratory liver tests are highly useful in the evaluation and treatment of patients with hepatic dysfunction. It has been found that some of the enzymes and the end products of the metabolic pathway such as serum bilirubin, alanine amino transferase, aspartate amino transferase, ratio of aminotransferases, alkaline phosphatase, gamma glutamyl transferase, 5’ nucleotidase, ceruloplasmin that are very sensitive for the abnormality occurred may be considered as an outstanding biochemical marker of liver dysfunction. It is noticed that the novel coronavirus Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) infection mostly leads to respiratory distress syndrome, at the same time liver injury is also documented. As a matter of fact, the mechanism of liver injury is limited and poorly understood. Therefore, the hepatic injury might be due to a consequence of systemic inflammatory response, viral infection of hepatocytes, or it comes as a result of intensive care treatment or drug toxicity. The host angiotensin-converting enzyme 2 (ACE2) receptors, which are widely distributed in type 2 alveolar cells, are the proposed route of viral entrance. It is interesting to note that ACE2 receptors are found in the liver's cholangiocytes, vascular endothelium, and gastrointestinal tract.

Scientific Type

اكاديمي

Link

https://www.journalofbabylon.com/index.php/JUBPAS/article/view/4522

Journal volume

vol.30,No.4

Collaboration type

مشترك

Publish Date

December 31, 2022

Participated Universities (Publication)

Alnoor University

Mosul University

Scopus status

Not in Scopus

Clarivate status

Not In Clarivate

Pub. Med. status

Not In PubMed

Author (Publication)

هديل طارق سعدون احمد

شيماء عبد الله احمد مديد

Journal (Publication)

JOURNAL of UNIVERSITY of BABYLON for Pure and Applied Sciences

Publisher (Publication)

جامعة بابل

ISSN

1992-0652

Country (Publication)

Iraq

Country type

داخل العراق

College (Publication)

College of Health and Medical Technologies

Departement (Publication)

Department of Medical laboratories techniques