A Green Indirect Spectrophotometric Estimation of the Analgesic Naproxen in the Existence of the Another Analgesic Paracetamol
- Title
- A Green Indirect Spectrophotometric Estimation of the Analgesic Naproxen in the Existence of the Another Analgesic Paracetamol
- Abstract
-
A novel and secure indirect spectrophotometric technique for estimation of naproxen as a coupled compound with paracetamol as a unharmed diazotized reagent than organic reagents. Naproxen was first converted into an active form to act as coupling agent by reflux with hydrobromic acid (HBr) and acetic acid (CH3COOH) to yield the Hydroxy Form of Naproxen (HFN). The diazotized complex absorb light in wavelength 500 nm. Beer's law linearity is 10 to 200 µg/20ml, (i.e. 0.5-10.0 ppm), the molar absorptivity (ɛ) is 2.14x104 l/mol.cm, Sandell's sensitivity index (SSI) is 0.0094 µg/cm which indicate a high sensitivity, RSD more than ±0.36 % indicate good precision and higher accuracy (relative error more than 0.82 %), and LOD = 0.024 µg/ml and LOQ = 0.079 µg/ml. The technique has been used effectively for estimation of naproxen in tablets.
- Scientific Type
- اكاديمي
- Journal volume
- vol.65,No.1
- Collaboration type
- مشترك
- Publish Date
- January 1, 2022
- Participated Universities (Publication)
-
Alnoor University
- Scopus status
- In Scopus
- Scopus index year
- 2 022
- Scopus quarter
- 3
- Scopus citation score
- 1.899999976
- Clarivate status
- In Clarivate
- Clarivate index year
- 2 022
- Clarivate impafact
- 0.219999999
- Pub. Med. status
- Not In PubMed
- Journal (Publication)
- Egyptian Journal of Chemistry
- Publisher (Publication)
- National Information and Documentation Centre(NIDOC)
- ISSN
- 0449-2285
- Country (Publication)
-
Egypt
- Country type
- عربية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy