Dapsone as Novel Reagent for Determination of Doxycycline via Diazotisation Coupling Reaction
- Title
- Dapsone as Novel Reagent for Determination of Doxycycline via Diazotisation Coupling Reaction
- Abstract
-
A sensitive, simple, accurate, and precious spectrophotometric method for the determination of doxycycline (Dox) was developed and applied in both pure and pharmaceutical form. The reaction is based on the dapsone diazotization in a hydrochloric acid solution with sodium nitrite. The salt formed in diazonium is then reacted to form yellow-orange azo- dye with doxycycline in the sodium hydroxide solution, showing a maximum absorption at 468 nm. The law of beer obeyed in the concentration range of 1-8.2μg mL-1 and molar absorption is 5.573 × 104 L mol-1 cm-1. The relative standard deviation is ≤ 2, and the average recovery is 98.7%. The method was suitable for determining doxycycline in its pharmaceutical preparation, as a capsule, with no interference by widely known excipients used as additives in its commercial formulations. The finding aligns favorably with the official method.
- Scientific Type
- اكاديمي
- Journal volume
- vol.11,No.1
- Collaboration type
- مشترك
- Publish Date
- March 25, 2021
- Scopus status
- In Scopus
- Scopus index year
- 2 021
- Scopus quarter
- 3
- Scopus citation score
- 0.400000006
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
انمار غانم تقي إبراهيم
- Journal (Publication)
-
International Journal of Drug Delivery Technology
- Publisher (Publication)
- Dr. Yashwant Research Labs Pvt. Ltd.
- ISSN
- 0975-4415
- Country (Publication)
-
India
- Country type
- عالمية
- College (Publication)
-
College of Health and Medical Technologies
- Departement (Publication)
-
Department of Radiology
- Media
-
Academic Paper
Part of Dapsone as Novel Reagent for Determination of Doxycycline via Diazotisation Coupling Reaction