Impact of Metformin on Pro-inflammatory Cytokines and Histological Evaluation of the Liver Induced Diabetes on Albino Male Rats
- Title
- Impact of Metformin on Pro-inflammatory Cytokines and Histological Evaluation of the Liver Induced Diabetes on Albino Male Rats
- Abstract
-
This study aimed to assess metformin effect with different concentration and duration on pro-inflammatory factors serum and tissue of liver and its impact upon the liver of diabetic albino rats. Metformin is administered in multi doses at various times to diabetic rats. Alloxan injected to induced diabetes in the rats, and then metformin was administered by gavage; then blood and tissue collected to analyze the biochemical parameters (a pro-inflammatory cytokine), serum blood glucose, body weight blood, and tissue were collected. Liver tissues were collected for histologic analysis at the beginning of experiments day 0, days 7, days 21, and days 35 (end of experiments) and sacrificed three animals for each period. The findings metformin-treated diabetic rat showed significant changes observed in terms of body weight and food intake behavior. Metformin treatment dropped serum blood glucose levels in diabetic rats. Following metformin treatment, an ELISA assay indicated dropped levels of pro-inflammatory markers in the liver tissues and serum. Further, metformin treatment reduced the intensity of liver inflammation measured by pathologists blindly. Conclusion: The results of reducing pro-inflammatory cytokines in the liver tissues and serum recommend the anti-inflammatory effects of metformin to improve inflammation.
- Scientific Type
- غير معروف
- Journal volume
- vol.11,No.4
- Collaboration type
- مشترك
- Publish Date
- December 25, 2021
- Scopus status
- In Scopus
- Scopus index year
- 2 021
- Scopus quarter
- 4
- Scopus citation score
- 0.400000006
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
عصام حمو محمود شهاب
- Journal (Publication)
-
International Journal of Drug Delivery Technology
- Publisher (Publication)
- Dr. Yashwant Research Labs Pvt. Ltd.
- ISSN
- 0975-4415
- Country (Publication)
-
India
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic Paper
