Investigation on the Possible Cutaneous Toxicity of Silver Nanoparticles in Swiss Albino Rats

Title

Investigation on the Possible Cutaneous Toxicity of Silver Nanoparticles in Swiss Albino Rats

Abstract

Due of its potent antibacterial effect, nanosilver is among the most commonly used nanomaterials. As a result of this, there is a growing concern regarding the potential adverse effects of these nanoparticles due to the rising likelihood that humans may be exposed to nanosilver. In this research, we studied the possible cutaneous toxicity of silver nanoparticles in rats. The statistical population of this study consisted of 30 adult male Swiss albino rats (100-150g). They were acquired from animal farm of the Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), Cairo, Egypt. For this experiment, they were split into the treatment and control groups (n = 15) at random. Anesthetics were administered to all animals, and the backs were shaved around the spinal column in the nanosilver group and the control group, respectively. The sterile bandages of rats were then moistened with distilled water (in control) or a volume of 55µl of 15µg/ml of nanosilver solution (in treatment) before being adhered to the skin with cloth glue. The bandages were removed after 4 and 8 days, and standard kits were used to determine the serum levels of two groups of rats’ aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (Cr), and blood urea nitrogen (BUN). BUN, AST, and ALT levels in the treatment group over the experiment periods were significantly higher than those in the control group (p<0.05). According to the results of this study, 15µg/ml nanosilver (45nm) absorbed through the skin can cause renal toxicity and hepatotoxicity in rats.

Scientific Type

اكاديمي

Link

https://jns.kashanu.ac.ir/article_112821.html

Journal volume

vol.12,No.3

Collaboration type

مشترك

Publish Date

July 1, 2022

Participated Universities (Publication)

Alnoor University

Ahl AL Bayt University

Hilla University College

Mazaya University College

AL Farahidi University

Al Mustaqbal University College

Scopus status

In Scopus

Scopus index year

2 022

Scopus quarter

3

Scopus citation score

2

Clarivate status

In Clarivate

Clarivate index year

2 022

Clarivate impafact

0.261000007

Pub. Med. status

Not In PubMed

Author (Publication)

صفوان جاسم سلطان خليل

Journal (Publication)

Journal of Nanostructures

Publisher (Publication)

University of Kashan

ISSN

2251-7871

Country (Publication)

Iran

Country type

عالمية

College (Publication)

College of Dentistry

Departement (Publication)

Department of Dentistry