Silymarin's antioxidant and protective effects on isoniazid and rifampicin-induced liver and kidney tissue damage in adult rats.
- Title
- Silymarin's antioxidant and protective effects on isoniazid and rifampicin-induced liver and kidney tissue damage in adult rats.
- Abstract
- The objective of the present study was to investigate the possibility that silymarin could mitigate the harm that isoniazid (INH) and rifampicin (RIF) cause to male albino rats' hepatorenal tissues. Forty male albino rats were divided into four groups weighing (180-200 g) and each received a different treatment: The control group was group 1, which received normal saline orally (NaCl, 0.9%); Group 2 got isoniazid (100 mg/kg, i.p.) along with rifampicin (100 mg/kg, i.p.) in sterile water, Group 3 received silymarin (200 mg/kg/p.o.); and Group 4 also received silymarin (200 mg/kg/p.o.) and was given isoniazid (50 mg/kg/i.p.) and rifampicin (100 mg/kg/i.p.). It took 28 days to do this treatment once each day. Alanine aminotransferase (ALT), aspartate aminotransferase (ALT), total protein (TP), bilirubin, and glutathione (GSH) levels were measured as biomarkers. Additionally, histopathological examinations of the liver and kidney tissues of the experimental animals were carried out. Results indicated Rats used in experiments received isoniazid and rifampicin, which resulted in a considerable increase in liver marker enzyme levels and a significant decrease in TP and glutathione (GSH) levels. Silymarin use, however, improved these results. According to a histological investigation, taking Rifampicin and Isoniazid together damaged the hepatorenal tissue and congested the blood vessels. However, taking silymarin along with rifampicin-isoniazid reduced this damage, and improvements were seen in the tissue's levels of oxidative stress, inflammation, and some inflammatory cell markers after treatment with both test drugs.
- Scientific Type
- اكاديمي
- Journal volume
- الثالث والخامس
- Collaboration type
- مشترك
- Publish Date
- December 29, 2022
- Scopus status
- Not in Scopus
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Journal (Publication)
- سير المؤتمر العلمي الثالث والخامس / كلية العلوم / جامعة تكريت
- Publisher (Publication)
- جامعة تكريت
- Country (Publication)
-
Iraq
- Country type
- داخل العراق
- College (Publication)
-
College of Health and Medical Technologies
- Departement (Publication)
-
Department of Medical laboratories techniques
- Media
-
Academic Paper
