The Impact of PtNPs and CDDP on a Rabbit Hepatocellular Carcinoma Model

Title

The Impact of PtNPs and CDDP on a Rabbit Hepatocellular Carcinoma Model

Abstract

Hepatocellular carcinoma (HCC), the most common primary liver cancer, accounts for approximately 90% of all liver cancer cases. Asia and sub-Saharan Africa, where hepatitis B infection is common and many people are infected from birth, are the regions with the highest incidence of HCC cases and the lowest post-treatment survival rates. In order to treat rabbits with HCC, this study evaluated the anticancer activity of platinum nanoparticles (PtNPs) to that of cisplatin (CDDP). Measurement of antioxidant activity against diethylnitrosamine (DEN)-induced oxidative stress in liver tissue was used to assess the effectiveness of PtNP therapy. Malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, and reduced glutathione (GSH) content were all measured. In addition to assessing the liver tissue’s cytochrome c, caspase-3, and serum alpha-fetoprotein (AFP) levels, liver function tests have been also performed. The relative quantification of the genes for tumor protein p53, matrix metallopeptidase 9, and B-cell lymphoma 2 had also been carried out using complete RNA extraction from biopsies of liver tissue. Since it improved the study’s variables to those of typical control animals, the results demonstrated that PtNPs are more effective than CDDP in treating rabbit HCC brought on by DEN. In histological investigations of the DEN group treated with PtNPs, such results were well acknowledged. This suggests, therefore, that PtNPs can act as a promising agent for the treatment of HCC and could therefore interest future investigations.

Scientific Type

اكاديمي

Link

https://jns.kashanu.ac.ir/article_112835.html

Journal volume

vol.12,No.4

Collaboration type

مشترك

Publish Date

October 1, 2022

Participated Universities (Publication)

Alnoor University

Al-Manara College For Medical Sciences

Mazaya University College

Al Nisour University College

AL Farahidi University

Al Mustaqbal University College

Hilla University College

Scopus status

In Scopus

Scopus index year

2 022

Scopus quarter

3

Scopus citation score

2

Clarivate status

Not In Clarivate

Pub. Med. status

Not In PubMed

Author (Publication)

بشار راسم كريم يونس

Journal (Publication)

Journal of Nanostructures

Publisher (Publication)

Kashan University of Kashan

ISSN

2251-7871

Country (Publication)

Iran

Country type

عالمية

College (Publication)

College of Health and Medical Technologies

Departement (Publication)

Department of Medical laboratories techniques