Possible effects of glucosamine on gait assessment and lipid peroxidation in ovariectomized rabbits
- Title
- Possible effects of glucosamine on gait assessment and lipid peroxidation in ovariectomized rabbits
- Abstract
-
In routine physiological procedures and/or pathological conditions, the living tissues produce free radicals,
especially reactive oxygen species (ROS). It has been well documented that the primarily responsible mechanism
for cell damage and destruction would be the lipid peroxidation conducted by ROS. It is approved that human
articular chondrocytes actively lead to significant ROS production. DNA damage and telomere shortening have
been known as the most important consequences of any increase in ROS production. Therefore, the current
research was designed to investigate the effect of pre- and post- osteoarthritis administration of glucosamine on
induced osteoarthritis in rabbits. In this experiment, 20 adult female New Zealand white rabbits with an average
weight of 2.14 ± 0.45 kg were used. Visual inspection evaluated the animals to be free of any joints and muscular
disorders. The animals were randomly divided into 4 groups (n = 5); Group A was ovariectomized without any
treatments, while rabbits in Group B were ovariectomized, and after radiographic confirmation of OA, they were
administered 75 mg kg-1 glucosamine. Rabbits in Group C were neither ovariectomized nor administered
glucosamine, while rabbits in Group D were ovariectomized and administered glucosamine immediately after
ovariectomy. Rabbits' gaits were scored before ovariectomy and at 4, 8, 12, 18, and 24 weeks post-ovariectomy
(PO). Stifle joints radiographs and blood samples were obtained at 12, 18, and 24 weeks PO. Gait assessment
score (GAS) was significantly (p < 0.05) lower in group A than in groups B, C, and D. Plasma concentration of
TBARS was higher in groups A and B than in groups C and D, while plasma SOD decreased significantly (p <
0.05) between weeks 4 and 12 PO in all the groups. However, there were no significant differences in plasma
concentrations of GSH, GPx, GST, tCHOL, TRIG, HDL, and LDL in all the groups. It was concluded that
glucosamine inhibits lipid peroxidation; its prophylactic use has no significant advantage over its post-OA use. - Scientific Type
- غير معروف
- Journal volume
- vol.21,No.2
- Collaboration type
- مشترك
- Publish Date
- April 1, 2023
- Participated Universities (Publication)
-
Alnoor University
- Scopus status
- In Scopus
- Scopus index year
- 2 023
- Scopus quarter
- 3
- Scopus citation score
- 2.200000048
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
- شيماء عبد الله احمد مديد
- Journal (Publication)
-
Caspian Journal of Environmental Sciences
- Publisher (Publication)
- University of Guilan
- ISSN
- 1735-3033
- Country (Publication)
-
Iran
- Country type
- عالمية
- College (Publication)
-
College of Health and Medical Technologies
- Departement (Publication)
-
Department of Anesthesia Techniques
- Media
-
Academic Paper
Part of Possible effects of glucosamine on gait assessment and lipid peroxidation in ovariectomized rabbits