Spectrofluorimetric determination of Propranolol and Diclofenac medicines using fluorescein dye
- Title
- Spectrofluorimetric determination of Propranolol and Diclofenac medicines using fluorescein dye
- Abstract
- A spectrofluorimetric method for determining diclofenac sodium and propranolol hydrochloride in an aqueous medium has been described. The method is based on increasing the intensity of fluorescein dye fluorescence when diclofenac is added at an excitation wavelength of 353 nm and an emission wavelength of 513 nm, and quenching fluorescein dye fluorescence when propranolol is added at an excitation wavelength of 353 nm and an emission wavelength of 518 nm. The determination ranges for diclofenac sodium and propranolol hydrochloride were 2–18 and 0.2–7 µg/mL, respectively, with a limit of detection of 0.114 and 0.050 µg/mL, and a limit of quantitation of 0.382 and 0.170 µg/mL, respectively. The average recoveries were 100.25 and 97.95% with a relative standard deviation of less than 0.6% for both pharmaceuticals, respectively. The proposed method has been applied for the analysis of commercial tablets and injections containing the medications. A statistical comparison of the data with the official method revealed good agreement and demonstrated that there were no significant differences in the accuracy and precision of the two approaches.
- Scientific Type
- اكاديمي وتطبيقي
- Journal volume
- vol.79,No.3
- Collaboration type
- مشترك
- Publish Date
- February 26, 2024
- Participated Universities (Publication)
-
Alnoor University
- Scopus status
- In Scopus
- Scopus index year
- 2 023
- Scopus quarter
- 3
- Scopus citation score
- 2
- Clarivate status
- In Clarivate
- Clarivate index year
- 2 024
- Clarivate impafact
- 1.100000024
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
ضياء نجم عبدالله حسوني
- Journal (Publication)
- Journal of Analytical Chemistry
- Publisher (Publication)
- Pleiades Publishing
- ISSN
- 1061-9348
- Country (Publication)
-
Russian
- Country type
- عالمية
- College (Publication)
-
College of Health and Medical Technologies
- Departement (Publication)
-
Department of Optics Techniques
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