Extraction of some essential amino acids using aqueous two-phase systems made by sugar-based deep eutectic solvents · Alnoor Digital Repository

Title: Extraction of some essential amino acids using aqueous two-phase systems made by sugar-based deep eutectic solvents
Abstract: Aqueous two-phase systems (ATPSs) have long been recognized as versatile and efficient tools for the extraction of biomolecules, including amino acids. Recent advancements in the field have introduced a novel approach by utilizing deep eutectic solvents (DES) to form ATPs. This study aimed to determine the phase diagrams for an ATPS made of polyethylene glycol dimethyl ether 250 and two types of NADESs, namely choline chloride as a hydrogen bond acceptor (HBA), and either sucrose or fructose as a hydrogen bond donor (HBD) with a molar ratio of 1 : 2. The measured tie-line results revealed that the hydrogen bonds of NADES may not be entirely disrupted in aqueous solutions, and thus, these ATPSs act as ternary-like systems. Additionally, the binodal data were fitted using two semi-empirical equations, namely Merchuk and Zafarani-Moattar et al. equations. Furthermore, the ATPSs mentioned above were applied to extract three amino acids, namely L-arginine, L-phenylalanine, and L-tyrosine, and demonstrated good extraction levels. Finally, the Diamond–Hsu equation and its modified version were utilized to correlate the experimental partition coefficients of the amino acids. These advancements pave the way for the development of improved extraction methodologies and the exploration of new applications in the field of biotechnology, pharmaceuticals, and beyond.
Scientific Type: غير معروف
Link: https://pubs.rsc.org/en/content/articlelanding/2023/RA/D3RA03092J
Journal volume: vol.13,No.29,2023
Collaboration type: مشترك
Publish Date: June 29, 2023
Participated Universities (Publication): Alnoor University
Scopus status: In Scopus
Scopus index year: 2 023
Scopus quarter: 1
Scopus citation score: 7.099999905
Clarivate status: In Clarivate
Clarivate index year: 2 023
Clarivate impafact: 4.035999775
Pub. Med. status: In PubMed
Author (Publication): شاكر محمود سعيد مصطفى
Journal (Publication): RSC Advances
Publisher (Publication): Royal Society of Chemistry
ISSN: 2046-2069
Country (Publication): United kingdom
Country type: عالمية
College (Publication): College of Pharmacy
Departement (Publication): Department of Pharmacy

Media: Academic Paper