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Title
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Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies
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Abstract
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To assess the biological potential of an Er complex that contains a 2,2’-bipyridine
ligand, various techniques such as multispectral and molecular modeling
procedures were utilized to examine its DNA-binding ability, BSA binding
affinity, antimicrobial effects, and anticancer properties. By analyzing
fluorescent information and employing the vant’ Hoff equation, important
parameters such as the innate docking coefficient (Kb), Stern-Volmer
coefficient (KSV), and thermodynamic properties including modifications in
liberated energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°) were determined. The
trial findings suggest that the compound can bind to DNA, primarily through
groove binding. Additionally, the engagement between the Er compound and the
protein BSA was examined using emission spectroscopy technique, revealing a
powerful binding affinity between the compound and BSA. The Er complex binds
to BSA primarily via hydrogen links and van der Waals forces, as indicated by the
adverse values of ΔH° and ΔS°. Through a static quenching process, the complex
significantly reduces the intrinsic fluorescence of BSA. Molecular binding
calculations and rivalrous binding trials confirm that this compound dock to
hydrophobic remains found in site III of BSA. Additionally, the Er complex
demonstrates promising results in terms of its anticancer and antimicrobial
activities based on screening tests.
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Scientific Type
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غير معروف
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Journal volume
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vol.11,2023
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Collaboration type
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مشترك
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Publish Date
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August 28, 2023
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Scopus status
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In Scopus
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Scopus index year
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2 023
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Scopus quarter
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1
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Scopus citation score
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8
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Clarivate status
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In Clarivate
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Clarivate index year
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2 023
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Clarivate impafact
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5.545000076
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Pub. Med. status
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Not In PubMed
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ISSN
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2296-2646
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Country type
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عالمية
Alnoor University
United kingdom
College of Health and Medical Technologies
Department of Optics Techniques
Academic Paper 