Synthesis and Biological Activity of some New Nitrogenous Heterocyclic Compounds Derived from Azachalcone
- Title
- Synthesis and Biological Activity of some New Nitrogenous Heterocyclic Compounds Derived from Azachalcone
- Abstract
- A series of heterocyclic compounds containing oxygen and nitrogen atoms, isoxazoline ІI(a-d) and another containing two nitrogen atoms, pyrazolinesІII(a-d) and phenylpyrazolines IV(a-d) were prepared by the reaction of a proper azachalcones І(a-d) with hydroxylaminehydrochloride, hydrazine hydrate or phenylhydrazine. These heterocyclic compounds were characterized by 1 H-NMR , CHN , IR and UV spectra in addition to their some physical properties. Also, these prepared compounds were screened for their biological activities and a theoretical calculation which shows that the product IVa obtained from 1,2 – rout was energetically more stable by 1.3967 kcal/mole than that came from 1,4 – rout, thus the reaction proceed via 1,2 – addition.
- Scientific Type
- اكاديمي
- Journal volume
- vol.28,No.2
- Collaboration type
- مشترك
- Publish Date
- June 1, 2019
- Scopus status
- Not in Scopus
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
شاكر محمود سعيد مصطفى
- Journal (Publication)
- مجلة علوم الرافدين
- Publisher (Publication)
- جامعة الموصل
- ISSN
- 1608-9391
- Country (Publication)
-
Iraq
- Country type
- داخل العراق
- College (Publication)
-
College of Dentistry
- Departement (Publication)
-
Department of Dentistry
- Media
-
Academic paper
