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Title
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protective role of cranberry Extract Against Zovirax-Induced Spleen Dysfunction in Adult Female Wistar Rats.
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Abstract
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This research explored a possible protective function of antioxidants, such as cranberries, against zoviraxinduced spleen dysfunction in adult female Wistar rats. A collection of 24(adult female Wistar rats) was haphazardly appointed to four equal sets, each including six animals. They received the following treatment for (0–22–44) days per day. The first group, known as group (C), was obtained in (tap water), and served as a control. The second set (A1) obtained orally 150 mg/kg B.W. of cranberry alone. The third group (A2) received zovirax (450mg/kg B.W.) during the trial to elicit spleen toxicity. In the fourth group (A3), zovirax (450mg/kg B.W.) was administered, plus cranberry (150mg/kg B.W.) was used to alleviate symptoms. Blood samples taken from the orbital sinus were obtained on days (0, 22, and 44) of the experiment, after a fast, to test the serum levels of albumin, total bilirubin (T.B.), globulin, and total serum protein (T.S.P.). After the experiment, splenic slices were taken out for histological analysis. The findings showed that the quantities of total blood protein, albumin, and total bilirubin significantly decreased in rats given zovirax (A2) at a significance level of (P≤ 0.01), accompanying histopathological investigation alterations regarding the histological composition of spleen tissue sections to treat all other sets. However, the protecting function of cranberries was elucidated in the set (A1), encompassing both the histopathological changes and correction of the spleen function mentioned above. Based on these facts, we have determined the results of this study confirmed that cranberries, as an antioxidant, can protect the spleen against zovirax-induced damage in adult females
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Scientific Type
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اكاديمي
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Journal volume
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بدون
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Collaboration type
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مشترك
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Publish Date
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March 6, 2024
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Scopus status
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Not in Scopus
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Scopus citation score
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0
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Clarivate status
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Not In Clarivate
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Pub. Med. status
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Not In PubMed
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ISSN
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978-625-99934-1-6
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Country type
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عالمية
Turkey
College of Health and Medical Technologies
Department of Optics Techniques
Academic paper 