Highly development and validation of a spectrophotometric method for Mogadon drug in pharmaceutical tablets by diazotization reaction · Alnoor Digital Repository

Title: Highly development and validation of a spectrophotometric method for Mogadon drug in pharmaceutical tablets by diazotization reaction
Abstract: This method was based on the use of the diazotization method, as a simple, sensitive method, and easy spectrophotometric way, for the determination of Mogadon drug or called Nitrazepam (NZP) in pharmaceutical tablets. This way depends upon the reduction of the nitro to amino group; reacts with reagent catechol to form a color complex with the best maximum absorption at 463 nm. The optimal conditions were studied for an experiment such as effect of base volume, effect of kind and acid volume, contact time, and temperature. The spectrophotometric way has been successfully useful to determine NZP in pharmaceutical tablets. The best absorbance as optimal volume NaOH at 1 mL and 1 mL HCl. Optimal time required to complete the azo coupling reaction was found to be 3 min for NZP drug. Where the range concentration 1-20 mg/10 mL, it obeys Lambert Beer Law Correlation coefficient (R2 =0.9982). The selectivity of the suggested was reveals the influence of number of some materials foreign (like lactose, starch, glucose, dextrose). The data show that the examined interferences non-overlap with suggested method. The recovery of NZP drug in tablets was in the range of (96% -100.1 %). The statistical result compared with these found by a way reported in literature. This simple, sensitive, and selective, method can be utilized to do control analysis for drug determination.
Scientific Type: غير معروف
Link: http://jmpcr.samipubco.com/article_181185.html
Journal volume: vol.5,No.11
Collaboration type: مشترك
Publish Date: January 11, 2023
Participated Universities (Publication): Alnoor University
Scopus status: In Scopus
Scopus index year: 2 023
Scopus quarter: 5
Scopus citation score: 0
Clarivate status: Not In Clarivate
Pub. Med. status: Not In PubMed
Author (Publication): حنان حسن احمد عباس
Journal (Publication): Journal of Medicinal and Pharmaceutical Chemistry Research
Publisher (Publication): Sami Publishing Company
ISSN: 2981-0221
Country (Publication): Iran
Country type: عالمية
College (Publication): College of Pharmacy
Departement (Publication): Department of Pharmacy

Media: Academic paper