Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms
- Title
- Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms
- Abstract
-
There is a growing interest to understand the role and mechanism of action of microRNAs (miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that regulate fundamental cellular processes through mRNA targeting in multicellular organisms. The miR-150 is one of the miRNAs that have a crucial role during tumor cell progression and metastasis. Based on accumulated evidence, miR-150 acts as a double-edged sword in malignant cells, leading to either tumor-suppressive or oncogenic function. An overview of miR-150 function and interactions with regulatory and signaling pathways helps to elucidate these inconsistent effects in metastatic cells. Aberrant levels of miR-150 are detectable in metastatic cells that are closely related to cancer cell migration, invasion, and angiogenesis. The ability of miR-150 in regulating of epithelial-mesenchymal transition (EMT) process, a critical stage in tumor cell migration and metastasis, has been highlighted. Depending on the cancer cells type and gene expression profile, levels of miR-150 and potential target genes in the fundamental cellular process can be different. Interaction between miR-150 and other non-coding RNAs, such as long non-coding RNAs and circular RNAs, can have a profound effect on the behavior of metastatic cells. MiR-150 plays a significant role in cancer metastasis and may be a potential therapeutic target for preventing or treating metastatic cancer.
- Scientific Type
- غير معروف
- Journal volume
- vol.23,No.1
- Collaboration type
- مشترك
- Publish Date
- November 3, 2023
- Participated Universities (Publication)
-
Alnoor University
- Scopus status
- In Scopus
- Scopus index year
- 2 023
- Scopus quarter
- 1
- Scopus citation score
- 10.5
- Clarivate status
- In Clarivate
- Clarivate index year
- 2 023
- Clarivate impafact
- 6.434999943
- Pub. Med. status
- In PubMed
- Author (Publication)
- هاني مسلم احمد محمد
- Journal (Publication)
-
Cancer Cell International
- Publisher (Publication)
-
Springer Nature
- ISSN
- 1475-2867
- Country (Publication)
-
United kingdom
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic paper
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