The Developmental Hepatotoxicity of Titanium Dioxide Nanoparticles in NMRI Mouse Neonates · Alnoor Digital Repository

Title: The Developmental Hepatotoxicity of Titanium Dioxide Nanoparticles in NMRI Mouse Neonates
Abstract: This study aimed to investigate the potential hepatotoxic effects of titanium dioxide nanoparticles (TiO2 NPs) on neonatal NMRI mice through maternal milk exposure. A total of 20 postpartum dams were divided into two groups: the experimental group received 30 mg/kg of TiO2 NPs, while the control group received deionized water for 14 days. The offspring were analyzed for oxidative stress markers, bioaccumulation, and histopathological changes in hepatic tissues. The results showed no significant difference in body weight or liver-to-body weight ratio between the treatment and control groups. However, oxidative stress was evident in the treatment group, with a significant reduction in glutathione (GSH) levels (0.8 µmol/g tissue, p<0.05) and glutathione peroxidase (GPx) activity (3.68 u/g tissue, p<0.05), compared to the control group. Additionally, malondialdehyde (MDA) levels, indicative of lipid peroxidation, were significantly higher in the treatment group (96 nmol/g tissue, p<0.001). TiO2 content was markedly increased in the treatment group’s liver (22.4 ng/g tissue, p<0.001) and stomach milk (41.6 ng/g tissue, p<0.001), suggesting bioaccumulation. Histological analysis revealed pronounced tissue degeneration and vascular changes in the treatment group’s hepatic tissues, contrasting with the normal histology observed in the control group. These findings indicate that maternal ingestion of TiO2 NPs can lead to oxidative stress and potential hepatotoxicity in neonatal mice, with significant implications for environmental and consumer product safety regulations.
Scientific Type: غير معروف
Link: https://jns.kashanu.ac.ir/article_114305.html
Journal volume: vol.13,issue3
Collaboration type: مشترك
Publish Date: July 1, 2023
Participated Universities (Publication): Alnoor University
Scopus status: In Scopus
Scopus index year: 2 023
Scopus quarter: 3
Scopus citation score: 2.700000048
Clarivate status: In Clarivate
Clarivate index year: 2 023
Clarivate impafact: 0.899999976
Pub. Med. status: Not In PubMed
Author (Publication): معن موفق نايف محمد
Journal (Publication): Journal of Nanostructures
Publisher (Publication): University of Kashan
ISSN: 2251-7871
Country (Publication): Iran
Country type: عالمية
College (Publication): College of Dentistry
Departement (Publication): Department of Dentistry

Media: Academic paper