Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
- Title
- Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
- Abstract
- Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.
- Scientific Type
- غير معروف
- Journal volume
- Volume 41, article number 201
- Collaboration type
- مشترك
- Publish Date
- July 13, 2024
- Participated Universities (Publication)
-
Alnoor University
- Scopus status
- In Scopus
- Scopus index year
- 2 024
- Scopus quarter
- 2
- Scopus citation score
- 4.199999809
- Clarivate status
- In Clarivate
- Clarivate index year
- 2 024
- Clarivate impafact
- 5.400000095
- Pub. Med. status
- In PubMed
- Author (Publication)
- محمد عبدالرزاق حميد حمودي
- Journal (Publication)
-
Medical Oncology
- Publisher (Publication)
-
Springer Nature
- ISSN
- 1357-0560
- Country (Publication)
-
United kingdom
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
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