Application of Mesenchymal Stem Cells and Exosome alone or Combination Therapy as a Treatment Strategy for Wound Healing · Alnoor Digital Repository

Title: Application of Mesenchymal Stem Cells and Exosome alone or Combination Therapy as a Treatment Strategy for Wound Healing
Abstract: The process of wound healing consists of multiple phases, and any disruptions in these phases can lead to the wound becoming chronic and impose heavy financial and psychological costs on the patient and a huge economic burden on the country’s healthcare system. Various treatments such as drugs, matrix and scaffolds, blood products, cell therapy, and a combination of these treatments are used for wound healing. The use of mesenchymal stem cells (MSCs) is one of these methods that have produced appropriate responses in the healing of patients’ wounds. MSCs by secreting growth factors, cytokines, chemokines, and RNAs elicit changes in cell proliferation, migration, growth, signaling, immunomodulation, and wound re-epithelialization process, and as a result, accelerate wound closure and wound healing. These cells can be isolated from different body sources with different cell characteristics and used directly on the wound site or by injection. In addition, MSCs-derived exosomes have attracted growing attention due to circumventing concerns relating to the direct use of MSCs. To increase the performance of MSCs, they can be used together with other compounds such as platelets, matrices, or scaffolds. This study examined the functions of MSCs in wound healing, as well as the vesicles they secrete, cellular and molecular mechanisms, and combined treatments with MSCs for wound healing.
Scientific Type: غير معروف
Link: https://link.springer.com/article/10.1007/s12013-024-01448-w
Journal volume: article in press
Collaboration type: مشترك
Publish Date: July 28, 2024
Participated Universities (Publication): Alnoor University
Scopus status: In Scopus
Scopus index year: 2 024
Scopus quarter: 2
Scopus citation score: 3.900000095
Clarivate status: In Clarivate
Clarivate index year: 2 024
Clarivate impafact: 2.900000095
Pub. Med. status: Not In PubMed
Author (Publication): مارب حميد احمد سعيد
Journal (Publication): Cell Biochemistry and Biophysics
Publisher (Publication): Springer Nature
ISSN: 1085-9195
Country (Publication): United States
Country type: عالمية
College (Publication): College of Dentistry
Departement (Publication): Department of Dentistry