Dehydroepiandrosterone supplementation improves diminished ovarian reserve clinical and in silico studies · Alnoor Digital Repository

Title: Dehydroepiandrosterone supplementation improves diminished ovarian reserve clinical and in silico studies
Abstract: The therapeutic role of dehydroepiandrosterone (DHEA) supplementation among infertile women with diminished ovarian reserve (DOR) is still unclear. Objective evaluation of different ovarian reserve tests (ORTs) such as serum anti-Mullerian hormone (AMH), serum follicle stimulating hormone (FSH), and antral follicle count (AFC) in women with diminished ovarian reserve is required. This is a cross-sectional study performed in Mosul city, Iraq, with 122 infertile women who had been diagnosed with DOR. The enrolled women’s age ranged from 18 to 45 years old (mean age of 29.46 ± 2.64 years). The ages of the enrolled women ranged from 18 to 45 years (mean age of 29.46 ± 2.64 years). To assess the influence of DHEA supplements (25 mg, three times/day for 12 weeks) across different age groups, the women were initially divided into three groups (18 to 27 years old, 28 to 37 years old, and ≥ 38 years old). Significant differences were noticed in AMH, FSH, level and AFC before and after DHEA supplementation. (AMH: 0.64 ± 0.82 vs. 1.98 ± 1.32, AFC: 2.86 ± 0.64 vs. 5.82 ± 2.42, and FSH: 12.44 ± 3.85 vs. 8.12 ± 4.64), statistically obvious significant differences regarding the results of AMH (p < 0.001), AFC (p < 0.001), and FSH (p < 0.001). DHEA supplementations improved the ovarian reserve of the enrolled women, which was more evident in younger women (<38 years old) than older women (≥38 years old). The AMH serum levels and AFC value can be considered the best, most reliable and significant OR parameters. However, large randomized multicenter studies are required to confirm the available results and data.
Scientific Type: غير معروف
Link: https://www.sciencedirect.com/science/article/abs/pii/S0039128X24001284
Journal volume: Volume 211
Collaboration type: مشترك
Publish Date: August 13, 2024
Participated Universities (Publication): Alnoor University
Scopus status: In Scopus
Scopus index year: 2 024
Scopus quarter: 2
Scopus citation score: 3.799999952
Clarivate status: In Clarivate
Clarivate index year: 2 024
Clarivate impafact: 2.700000048
Pub. Med. status: In PubMed
Author (Publication): هاني مسلم احمد محمد
Journal (Publication): Steroids
Publisher (Publication): Elsevier
ISSN: 0039-128X
Country (Publication): United States
Country type: عالمية
College (Publication): College of Pharmacy
Departement (Publication): Department of Pharmacy