Synthesis of Some New Hydrazones from Quinazolinone Moiety
- Title
- Synthesis of Some New Hydrazones from Quinazolinone Moiety
- Abstract
- Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (4) is one of the important heterocyclic compounds. It isused as a precursor to synthesis new derivatives of quinazolin-4-one moiety. The compound (4) was synthesized via a series of steps from anthranilic acid. The anthranilic acid was converted to its methyl ester (1) by esterification with methanol under acidic condition. The ester (1) was reacted with chloroacetyl chloride to produce methyl α-chloroacetamido benzoate (2). The chloro compound (2) was converted to the corresponding thiocyanato compound (3) by its reaction with ammonium thiocyanate. The thiocyanato compound (3) was cyclized to the target precursor (4) by boiling of compound (3) for 12 h. compound (4) was reacted with aromatic aldehydes under boiling condition to produce different hydrazones derivatives (5-12). The hydrazones compounds (5-12) were reacted with Chloroacetyl chloride to afforded the Azetedines compounds (13-20). The synthesized compounds were identified via the physical and spectral data.
- Scientific Type
- غير معروف
- Journal volume
- Volume: 16
- Collaboration type
- مشترك
- Publish Date
- December 31, 2021
- Scopus status
- In Scopus
- Scopus index year
- 2 021
- Scopus quarter
- 4
- Scopus citation score
- 0.200000003
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
- محمد احمد عبد الرزاق محمد
- Journal (Publication)
-
Eurasia Proceedings of Science, Technology, Engineering and Mathematics
- Publisher (Publication)
- N/A
- ISSN
- 2602-3199
- Country (Publication)
-
Turkey
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic paper
Part of Synthesis of Some New Hydrazones from Quinazolinone Moiety