Review Article: Oxidation: The Most Common Pathway for The Prodrugs Bio Precursors Activation.دراسة مرجعية :الأكسدة: المسار الأكثر شيوعًا لتنشيط السلائف الحيوية للعقاقير الأولية
- Title
- Review Article: Oxidation: The Most Common Pathway for The Prodrugs Bio Precursors Activation.دراسة مرجعية :الأكسدة: المسار الأكثر شيوعًا لتنشيط السلائف الحيوية للعقاقير الأولية
- Abstract
-
Oxidation of inactive prodrug (that their mode of action is
not via linkage carrier, but occur through modification of their
molecules which are called the bio precursor) to active parent
drug design is generally via the methods modification strategies
that aim to improve the physicochemical and pharmacological
properties of drugs such as increases bioavailability, water
solubility and/or duration of action.
These prodrugs need metabolically or chemical
transformation reactions to change to their active drugs, these
chemical reactions are generally formed by phase I reactions
through proton activation, elimination activation, oxidative
activation, reductive activation and phosphorylation activation
or decarboxylation activation.
The goal of this review is to study the up-to-date advances
in the prodrug’s oxidative activation such as N- and O- oxidative
dealkylation, oxidative deamination, N-oxidative and Soxidative important strategies to produce the parents’ active
drugs. Oxidation reactions are of great importance and most
cancerous diseases begin with these reactions. - Scientific Type
- اكاديمي
- Journal volume
- vol.32,No.3
- Collaboration type
- مشترك
- Publish Date
- September 1, 2023
- Scopus status
- Not in Scopus
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
-
شاكر محمود سعيد مصطفى
- Journal (Publication)
- مجلة علوم الرافدين
- Publisher (Publication)
- جامعة الموصل
- ISSN
- 1608-9391
- Country (Publication)
-
Iraq
- Country type
- داخل العراق
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic Paper
