Inhibitory Effect of ZrO2NPs on Candida Albicans in Heat-Cured Acrylic-Based Soft Lining Material

Title

Inhibitory Effect of ZrO2NPs on Candida Albicans in Heat-Cured Acrylic-Based Soft Lining Material

Abstract

The most prevalent issue that can contribute to persistent mucosal inflammation is the development of microorganisms and fungi, particularly Candida Albicans (C. albicans), on soft denture lining material. The objective of the current study is to identify the inhibitory effect of Zirconium Oxide Nanoparticles (ZrO2NPs) on C. albicans in heat-cured acrylic-based soft lining material and the quantity of zirconium ions (Zr) released by the composite of soft liner and ZrO2NPs. Soft denture liners made of acrylic were given varied ratios of ZrO2NPs. According to the test that will be conducted, 200 samples were separated into two groups (experimental and control). The soft liner/ZrO2NPs composite’s antifungal activity was evaluated utilizing two techniques over three distinct time periods (disk-diffusion test and viable count of C. albicans). Atomic Absorption Spectroscopy (AAS) was used to measure the amount of Zr emitted in synthetic saliva over two separate time periods. The strength of the soft liner’s shear bond to the denture base material made of acrylic was evaluated using an Instron testing equipment. Compared to the control group, there was a highly significant drop in C. albicans colony forming units in the experimental groups (1.5% and 2% ZrO2NPs). Once ZrO2NPs were added to soft liners at a rate of 2%, the shear bonding strength’s mean value increased in a manner that was highly significant. As a result of this research, ZrO2NPs could be incorporated into acrylic-based soft denture lining materials to give them antifungal qualities, which lower the risk of developing denture-induced stomatitis.

Scientific Type

اكاديمي

Link

https://jns.kashanu.ac.ir/article_112822.html

Journal volume

vol.12,No.3

Collaboration type

مشترك

Publish Date

July 1, 2022

Participated Universities (Publication)

Alnoor University

Al Mustaqbal University College

Ahl AL Bayt University

AL Farahidi University

Al Nisour University College

Hilla University College

Belgorod State National Research University

Mazaya University College

Scopus status

In Scopus

Scopus index year

2 022

Scopus quarter

3

Scopus citation score

2

Clarivate status

In Clarivate

Clarivate index year

2 022

Clarivate impafact

0.261000007

Pub. Med. status

Not In PubMed

Author (Publication)

زينة ضبيان محمد زكي

Journal (Publication)

Journal of Nanostructures

Publisher (Publication)

Kashan University of Kashan

ISSN

2251-7871

Country (Publication)

Iran

Country type

عالمية

College (Publication)

College of Dentistry

Departement (Publication)

Department of Dentistry