Pharmacology of Endogenous Opioids, Opiates and Their Receptors
- Title
- Pharmacology of Endogenous Opioids, Opiates and Their Receptors
- Abstract
-
The search for analgesia is the main drive for the discovery of opioid receptors and their endogenous ligand peptides. Although opioid peptides are very similar in their N-terminal sequence, they are classified into different types according to their precursor proteins. The peptides activate opioid receptors by binding to orthosteric-binding sites to mediate intracellular second messengers. Biased signaling and allosteric modulation is a new approach to obtain receptor subtype selectivity and separates the desirable from a myriad of unwanted pharmacological effects. This chapter describes endogenous opioids and opiates with an emphasis on structure, origin and processing, receptors, physiological roles, and potential involvement in therapeutic interventions. Further, it also provides a brief discussion on the effect of opioids on various ion channels and recent developments of established and investigational opioid molecules.
- Scientific Type
- غير معروف
- Journal volume
- Book Chapter
- Collaboration type
- مشترك
- Publish Date
- October 30, 2020
- Participated Universities (Publication)
-
Alnoor University
-
Assam University
- Sushrutu School of Medical & Paramedical Sciences
- Scopus status
- In Scopus
- Scopus index year
- 2 020
- Scopus quarter
- 5
- Clarivate status
- Not In Clarivate
- Pub. Med. status
- Not In PubMed
- Author (Publication)
- محمد نورالدين محمود عبد الله
- Journal (Publication)
- Frontiers in Pharmacology of Neurotransmitters
- Publisher (Publication)
- Springer Singapore
- ISSN
- ISBN: 978-981153556-7
- Country (Publication)
-
Switzerland
- Country type
- عالمية
- College (Publication)
-
College of Pharmacy
- Departement (Publication)
-
Department of Pharmacy
- Media
-
Academic Paper
Part of Pharmacology of Endogenous Opioids, Opiates and Their Receptors